How to Lose a Guy in 10 Days is a 2003 romantic comedy film directed by Donald Petrie, from a script by Kristen Buckley, Brian Regan, and Burr Steers, and starring Kate Hudson and Matthew McConaughey. Loosely based on the picture book of the same name by Michele Alexander and Jeannie Long, the plot concerns a women's magazine writer and an advertising executive who both begin a relationship with ulterior motives. While the story and characters in the film are original, the dating "don'ts" of the picture book are included in the film.

How to Lose a Guy in 10 Days was released theatrically in the United States on February 7, 2003, and was a box office success, grossing over $177.5 million against a production budget of $50 million. Despite this, the film garnered mixed reviews from critics, who praised Hudson and McConaughey's acting and chemistry, but criticized the script and predictable plot.