Marie and Bruce is a 2004 American comedy drama film directed by Tom Cairns, and starring Julianne Moore and Matthew Broderick. The story spans one day of a couple's dysfunctional, strained relationship.

It was based on the 1978 play of the same name by Wallace Shawn, who also wrote the screenplay with Cairns, and premiered at the Sundance Film Festival on January 19, 2004. Although the film was well received and starred major motion picture stars, it failed to receive distribution.

It remained obscure until it was released on DVD in March 2009. The music was composed by Mark Degli Antoni, of the band Soul Coughing.