The 2010 Destination X was a professional wrestling pay-per-view (PPV) event produced by the Total Nonstop Action Wrestling (TNA) promotion. It took place on March 21, 2010 at the TNA Impact! Zone in Orlando, Florida. The event was originally d as an all X Division pay-per-view. It was the sixth event under the Destination X chronology and the third event of the 2010 TNA PPV schedule.

In October 2017, with the launch of the Global Wrestling Network, the event became available to stream on demand.