Oprah with Meghan and Harry is a 2021 television special hosted by American media personality Oprah Winfrey, that featured an interview between Winfrey, Meghan, Duchess of Sussex, and Prince Harry, Duke of Sussex. The special premiered March 7, 2021, on CBS in the United States, and in the United Kingdom the next day on ITV.

Filmed in Santa Barbara County, California, the interview came the year after Prince Harry and Meghan announced their decision to step down as working of the British royal family in January 2020. The interview included discussion of their courtship, wedding, their second child's sex (female), mental health struggles including Meghan's suicidal thoughts, and a shared sense of abandonment in of emotional and financial . Moreover, Meghan critiqued the British monarchy as an institution, while they both said one or more comments had been made privately to Harry by an unidentified individual within the royal family in relation to the skin color of their then-unborn son, Prince Archie. Also discussed was a royal title for Archie, the personal security of the couple, and Harry's estrangement from his father, Charles, and brother, William. Meghan's own relationship with her estranged family was also briefly touched upon.

The interview received high viewing figures, generated extensive media attention and mixed reaction from political figures. The special was nominated for a 2021 Television Critics Award, a Primetime Emmy Award, and a People's Choice Award.